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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TP1856 | Colivelin | Beta Amyloid , STAT | |
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN). | |||
T9989 | AChE-IN-27 | Others | |
AChE-IN-27 is a small molecule used for high-throughput assays. | |||
T1476 | Pramipexole | SND 919 | Dopamine Receptor |
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not... | |||
T1594 | Vecuronium bromide | ORG NC 45 | AChR |
Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity. | |||
T7805 | GW791343 dihydrochloride | GW791343 (HCl) | P2X Receptor |
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator. | |||
T4497 | Amifampridine | 3,4-Pyridinediamine,Pyridine-3,4-Diamine,3,4-Diaminopyridine | Others |
Amifampridine (3,4-Diaminopyridine) is predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is ... | |||
T3217 | PF-CBP1 hydrochloride | PF-CBP1 HCl | Epigenetic Reader Domain , Histone Acetyltransferase |
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. | |||
T3198L | PRE-084 hydrochloride | Sigma receptor | |
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay). | |||
T6951 | Pramipexole dihydrochloride hydrate | Pramipexole 2HCl Monohydrate,Mirapex | Dopamine Receptor |
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su... | |||
T35878 | N-(3-Aminopropyl)cyclohexylamine | Others | |
N-(3-Aminopropyl)cyclohexylamine, a derivative of cyclohexylamine, functions as a selective and competitive inhibitor of spermine synthase, making it suitable for research on neurological diseases[1]. | |||
T6526 | GW791343 trihydrochloride | GW791343 3HCl | P2X Receptor |
GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. | |||
T28441 | PPI-1019 | PPI1019,Apan | Beta Amyloid |
PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD). | |||
T27143 | Delucemine Hydrochloride | NPS 1506,Delucemine,Delucemine HCl,NPS1506,NPS-1506 | NMDAR |
Delucemine Hydrochloride (Delucemine) is a polyamine NMDA receptor antagonist used in the study of neurological disorders such as depression and Alzheimer's disease. | |||
T31079 | CP-810123 | CP 810123,UNII-E6G4550EC4,CP810123 | AChR |
CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease. | |||
TP1866L | β-amyloid 1-11 acetate(190436-05-6 free base) | Beta Amyloid | |
β-amyloid 1-11 acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. | |||
TP1195 | Cibinetide | ARA290 | Others |
Cibinetide (ARA290) is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment. | |||
T13047 | Synta66 | Calcium Channel | |
Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease. | |||
T64344 | N-Methyl-DL-aspartic acid | NMDAR | |
N-Methyl-DL-aspartic acid, a glutamate analogue and NMDA receptor agonist, is utilized in neurological disease research. | |||
T68084 | Icopezil | AChE | |
Icopezil is a small molecule acetylcholinesterase in (AChE) inhibitor for the treatment of neurological disorders and can be used in the study of Alzheimer's disease. | |||
T11949 | Masupirdine mesylate | SUVN-502 mesylate,SVN-502 mesylate | 5-HT Receptor |
Masupirdine mesylate (SUVN-502 mesylate) is a selective 5-HT6 receptor antagonist that crosses the blood-brain barrier.Masupirdine mesylate is used in the study of neurological disorders such as Alzheimer's disease and d... | |||
TQ0238 | Lanabecestat | LY3314814,AZD3293 | BACE |
Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier.Lanabecestat can be used for the study of neurological diseases such as Alzh... | |||
T32368 | KB-74935 | KB 74935 | Others |
KB-74935 is an enzyme inhibitor and a mineralocorticoid receptor antagonist used to treat cholesterol, hypolipidemia, neurological disorders, and Alzheimer's disease. | |||
TP1214L | β-Amyloid 15-21 acetate | Beta-Amyloid (15-21) acetate | Beta Amyloid |
β-Amyloid 15-21 acetate (Beta-Amyloid (15-21) acetate) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation. | |||
T76726 | Zagotenemab | LY33003560 | Microtubule Associated |
Zagotenemab is a humanized antibody against the microtubule-associated protein tau that selectively regulates tau deposits in the brain. Zagotenemab can be used to study neurological disorders such as Alzheimer's disease... | |||
T26551 | Acetyl-L-carnitine | RO 447190,L-Acetylcarnitine,LAC,L-O-Acetylcarnitine,ALCAR,Acetyl L carnitine | Endogenous Metabolite |
Acetyl-L-carnitine(RO 447190) is an amino acid that crosses the blood-brain barrier and is often used as a dietary supplement for neuroinflammation.Acetyl-L-carnitine is neuroprotective and can be used in the study of ne... | |||
T68492 | AM 374 | HDSF,Hexadecanesulfonyl fluoride | FAAH |
AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease resear... | |||
T27795L | (Iso)-Landipirdine | (Iso)-SYN120,(Iso)-RO5025181,(Iso)-Landipirdine(Iso-1000308-25-7) | 5-HT Receptor |
(Iso)-Landipirdine((Iso)-RO5025181) is a selective and potent 5-HT6R antagonist. (Iso)-Landipirdine has a significant effect on the hERG pharmacophore and can be used to study neurological disorders in the Alzheimer's di... | |||
T50046 | 2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid hydrochloride | Others | |
2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid hydrochloride is an amino acid compound that is a synthetic analog of glutamate, an important neurotransmitter in the central nervous system. It has been investigated... | |||
T9340 | 1-phenyl-3,4-dihydroisochinoline | 3,4-Dihydro-1-phenylisoquinoline | Others |
1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) is a structural analog of the neurotransmitter dopamine that interacts with dopamine receptors in the central nervous system. It has been studied as a p... | |||
T111959 | IFB-088 acetate | ||
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... | |||
T50090 | 3-(2-phenylethynyl)pyridine | Others | |
3-(2-phenylethynyl)pyridine is a pyridine derivative that is a ligand for a variety of receptors in the human body, including dopamine D2 receptors, sigma-1 receptors, and 5-HT6 receptors. It has been studied for the tre... | |||
T50003 | Debrisoquin hydriodide | 1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide | Others |
Debrisoquin hydriodide (1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide) has antioxidant, anti-inflammatory and neuroprotective properties. It has also been found to modulate the activity of certain neurotra... | |||
T11948 | Masupirdine free base | Masupirdine,SUVN-502 free base | 5-HT Receptor |
Masupirdine free base (SUVN-502 free base) is an orally available 5-HT6 receptor antagonist that crosses the blood-brain barrier and has a Ki value of 2.04 nM for the human 5-HT6 receptor.Masupirdine free base is potent ... | |||
T77342 | GSK-3 inhibitor 3 | GSK-3 , Microtubule Associated | |
GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau ... | |||
T39218 | (S)-CVN424 | (S)-CVN424 | |
(S)-CVN424 is a powerful modulator of G-Protein-Coupled Receptor 6 (GPR6), known for its involvement in neurological and psychiatric disorders research, such as Parkinson's disease. | |||
T75969 | β-Amyloid (15-21) | ||
β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease . | |||
T7352L | Pridopidine hydrochloride | ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride | |
Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor ... | |||
T74031 | Cardiolipin (Heart, Bovine) (sodium) | ||
Cardiolipin (Heart, Bovine) Sodium, a phospholipid exclusive to mitochondria, shows potential for neurological disease research [1]. | |||
T79191 | AMPA receptor modulator-5 | iGluR | |
AMPA Receptor Modulator-5 (Example 217) serves as an AMPA receptor modulator, utilized in neurological disease research [1]. | |||
T81520 | Penta-alanine | Penta-L-alanine | |
Penta-alanine (Penta-L-alanine) is a peptide with potential applications in neurological disease research [1] [2]. | |||
T40701 | Ezeprogind | AZP-2006 | |
Ezeprogind (AZP-2006) is an orally active neurotrophic inducer that effectively addresses the underlying factors contributing to neurodegeneration, with a broad scope extending beyond the conventional targets like Abeta ... | |||
T80468 | δ-Dendrotoxin | Potassium Channel | |
δ-Dendrotoxin is a potassium (K+) channel blocker derived from black mamba snake venom and is utilized in neurological disease research [1]. | |||
TP1214 | β-Amyloid 15-21 | Beta-Amyloid (15-21) | |
β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation. | |||
T78111 | NCS-382 sodium | GABA Receptor | |
NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease research [1]. | |||
T81817 | Met-Arg-Phe-Ala | ||
Met-Arg-Phe-Ala, a peptide, serves as a potent competitive inhibitor of enkephalin-generating endopeptidase (EGE) and is utilized in neurological disease research [1]. | |||
T80484 | Aa1 toxin | Potassium Channel | |
Aa1 toxin, sourced from Androctonus australis Garzoni venom, is a neurotoxic peptide that specifically blocks potassium channels and has applications in neurological disease research [1]. | |||
T75257 | 4-Butyl-alpha-agarofuran | ||
4-Butyl-alpha-agarofuran (AF 5), an α-agarofuran derivative isolated from Gharu-wood, functions as an anxiolytic and antidepressant agent. It is utilized in neurological disease research [1]. | |||
T75875 | α-Conotoxin PnIA TFA | ||
α-Conotoxin PnIA TFA, a potent and selective antagonist of the mammalian α7 nAChR, holds promise for neurological research, particularly in studying neuropathic pain and Alzheimer's disease [1]. | |||
T70196 | AZD1446 HCl | ||
AZD1446 HCl, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 HCl showed favorable pharmaceutical properties and in vivo ... | |||
T72410 | Sortilin antagonist 1 | ||
Sortilin Antagonist 1, a potent sortilin antagonist, exhibits an inhibition constant (IC50) of 20 nM against Neurotensin (NTS) binding to sortilin. Neurotensin acts as a sortilin ligand. This compound is utilized in neur... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T1045 | Trimipramine maleate | Surmontil maleate | Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Norepinephrine , Histamine Receptor |
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal... | |||
T8790 | 1-Methylhistamine dihydrochloride | Endogenous Metabolite | |
1-Methylhistamine dihydrochloride is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains... | |||
T32614 | L-Clausenamide | (-)-Clausenamide | Microtubule Associated |
L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents t... | |||
T7984 | 2-Hydroxyflavanone | Others | |
2-Hydroxyflavanone is a naturally occurring flavonoid found in many plants and fruits. It has antioxidant, anti-inflammatory and anti-tumor activity, scavenging free radicals, reducing inflammation and inhibiting the gro... | |||
TN4368 | Kaempferol-3,7-di-O-β-glucoside | Kaempferol 3,7-di-O-glucoside | Glucosidase , Amylase |
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena, It can inhibit α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3, 7-di-o-β-Glucoside has neuroprotective ac... | |||
T3011 | 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid | Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine | Others , Endogenous Metabolite |
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) is a ketone and an amino acid derivative with diverse biological functions, including vasodilatory, immunoregulatory and neuromodulatory activities. 2-... | |||
T4S2126 | Ginkgetin | Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy | |
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 ... | |||
T82341 | Ganglioside GM1 | ||
Ganglioside GM1, a member of the ganglioside family, serves as a functional tissue receptor for Cholera Toxin1 [1] and is utilized in neurological disease research. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-06802 | HSV 2 (strain 333) Glycoprotein D/gD Protein (His) | HSV2 | HEK293 Cells |
Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Herpes simplex virus type 2 (HSV-2) infection is responsible for signific... | |||
TMPJ-01022 | SUMO3 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells |
Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way... | |||
TMPJ-01002 | SGSH Protein, Human, Recombinant (His) | Human | HEK293 Cells |
N-Sulphoglucosamine Sulphohydrolase (SGSH) is an important member of the sulfatase family which is involved in the degradation of heparin sulfate. SGSH binds one calcium ion per subunit as a cofactor. SGSH catalyzes N-su... | |||
TMPY-03332 | PRTFDC1 Protein, Human, Recombinant (His) | Human | E. coli |
PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG ... | |||
TMPY-01290 | CHIT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitina... | |||
TMPJ-00495 | ISG15 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protei... |
カタログ番号 | 製品名 | ||
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L4660 | Anti-Nervous System Disease Library | 1246 compounds | |
Well-chosen 1246 compounds with unique structures targeting nervous system; | |||
L7400 | Sodium Channel Blocker Library | 118 compounds | |
A unique collection of 118 sodium channel blockers and agonists for high throughput and high content screening; | |||
L2600 | Neuronal Signaling Compound Library | 2540 compounds | |
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L9840 | Anti-Alzheimer's Disease Compound Library | 986 compounds | |
A unique collection of 986 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS. | |||
L2630 | Neuronal Differentiation Compound Library | 672 compounds | |
L2610 | Neurotransmitter Receptor Compound Library | 1513 compounds | |
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening; |